Drug with fish oil cuts risk of heart attack, stroke, study finds
Heart Health Drug with fish oil cuts risk of heart attack, stroke, study finds “I think we’ve stumbled onto something here in terms of a new class of drugs,” said the lead author of the study. Nov. 11, 2018 01:43 Breaking News Emails Get breaking news alerts and special reports. The news and stories that matter, delivered weekday mornings. SUBSCRIBE Nov. 10, 2018 / 8:01 PM GMT By Linda Carroll and Lauren Dunn A fish oil-derived medication may lessen the likelihood of a heart attack or stroke in patients who are at high risk despite taking statin therapy, a new study finds. The medication, which contains high doses of the omega-3 fatty acid EPA, cut the risk of death due to cardiovascular causes, heart attack and stroke by 25 percent, the researchers found. And that was on top of the risk reduction brought about by cholesterol-lowering statins, according to the study, published Saturday in the New England Journal of Medicine. The patients in the new study all had elevated triglyceride levels, with nearly 71 percent having been diagnosed with atherosclerosis and/or already having had a heart attack or stroke and the rest with multiple risk factors, but no heart disease yet. Related Health Good Fats as Helpful as Statins Against Heart Disease, Group Says “I think we’ve stumbled onto something here in terms of a new class of drugs,” said Dr. Deepak Bhatt, a professor of medicine at Harvard Medical School and executive director of interventional cardiovascular programs at Brigham and Women’s Hospital in Boston. “Honestly, I think it’s as exciting as the statin era, when statins were first becoming available and we were learning about all the things that they can do. I view this as a similar sort of breakthrough.”
What we studied isn’t some over-the-counter unregulated supplement. It’s a prescription drug and very different from regular supplements. The drug, formally named icosapent ethyl — trade name Vascepa — contains a pure and stable form of EPA. Over-the-counter fish oil supplements contain some EPA along with other omega-3s, but in much lower doses than the prescription medication. Bhatt, the lead author of the study, stressed the fact that icosapent ethyl differs significantly from OTC fish oil supplements. “What we studied isn’t some over-the-counter unregulated supplement,” Bhatt said. “It’s a prescription drug and very different from regular supplements. It’s true it’s derived from marine sources, but it’s highly purified through a complex chemical process and it’s a prescription drug.” Multiple studies have shown that OTC fish oil supplements don’t protect the heart, Bhatt said. That might at least in part be because one of the other constituent omega-3s, DHA, seems to raise LDL, or “bad cholesterol,” he added. Related Health & Wellness More evidence shows seafood may help you stay healthier as you age The new study, a randomized, double-blind, placebo-controlled clinical trial, followed 8,179 patients with elevated triglycerides who either had diabetes plus another heart disease risk factor or had been diagnosed with atherosclerosis and/or had already suffered a heart attack or stroke, for 4.9 years. Patients either got 2 g of icosapent ethyl twice a day or a placebo that contained mineral oil. The trial was sponsored by the maker of Vascepa, Amarin Corporation. Patients were enrolled in the study if they were 45 or older and had established heart disease or were 50 or older and had diabetes plus another heart disease risk factor. Statins had already lowered the patients’ LDL levels, but they were still at high risk for death from cardiovascular disease. By the end of the study, hospitalization for chest pain, heart attack, stroke, cardiovascular death and procedures for coronary artery disease such as stenting had occurred in 17.2 percent of the patients taking icosapent ethyl, compared with 22 percent of the patients taking placebos. The researchers also reported a 24 percent reduction in cardiovascular death, nonfatal heart attack and nonfatal stroke —11.2 percent vs. 14.8 percent. While the drug did indeed reduce triglyceride levels, that reduction alone wasn’t enough to explain the size of the impact on heart disease in the group that got the drug, experts said. “I think this is going to be a landmark study,” said Dr. Michael Blaha, director of clinical research at the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease. “It’s remarkable.” With all the negative results in studies looking at OTC fish oil supplements to prevent heart disease, “I think expectations were low for this trial,” said Blaha, who was not involved in the new research. “But based on the clinical trial results, I haven’t seen anything this potent in this group of patients in a long time.” In fact, not since statins were introduced, Blaha said. The new findings “will absolutely have the potential to change the way we practice,” said Dr. Nisha Jhalani of the Center for Interventional Vascular Therapy at NewYork-Presbyterian Hospital/Columbia University Medical Center. “I think it’s very remarkable.” MORE FROM news
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