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Sunday 10 March 2019

Learn How Vitamins And Minerals Can Be Incorporated Into Your Life Easily

Although the idea of overhauling your diet and incorporating more vitamins and minerals can seem a little daunting, there are plenty of options for everyone (even those who hate vegetables!). Read this article for some great tips and tricks to make your diet more balanced and healthful for a happier body!

Working out is not enough for getting in shape; you also need to take vitamins. This will help you to prevent soreness so that you can get back to working out faster.

Do not assume that it is always safe to take any vitamins you want. If you have certain health conditions, it can be quite dangerous to take certain ones. You should also be careful if you take prescription medications since taking certain vitamins can cause a negative interaction with them.

Thiamine, or vitamin B1, deficiency can cause neurological and psychiatric symptoms. These symptoms can include weight loss, weakness, irregular heart rate and psychosis. A vitamin B complex can ensure you receive the vitamin B1 you need, or you can eat pork, brown rice, liver, oatmeal, leafy vegetables, eggs and potatoes.

If you decide to take a multivitamin, be sure you are choosing the right one. Some multivitamins do not contain all of the vitamins and minerals that truly benefit a person. Be sure to look for a multivitamin that contains vitamins A, B1, B2, B3, B5, B6, B7, B9, B12, C, D, E, and K. It should also have minerals zinc, selenium, chromium, copper, molybdenum, and magnesium.

Vitamin B9 is an essential vitamin for women. It will reduce high blood pressure, prevents heart disease, and helps reduce memory loss. Orange juice, eggs, melons, dark green vegetables and strawberries are all great foods that have high levels of vitamin B9. Many vitamin supplements are formulated for women with extra concentrations of B9.

While most vitamins can be stored at room temperature, you should store oil-based and gummy vitamins in the refrigerator. If you fail to do this, they may become sticky and clump together. Since there will be no definitive way to break them apart, this would render the entire bottle useless.

Use caution when using supplements. Even though vitamins and minerals can be healthy for your body, it can be bad if you take too much. This usually happens when you take too many supplements and is very dangerous. Depending on the vitamin, some of these overdoses can even threaten your life.

If you are having a struggle with the daily grind in life such as working multiple jobs and your household routine, you need to take more vitamins. When we are unable to allow our body time to unwind, we need more vitamins and minerals to keep it healthy and able to recover from a hectic schedule.

When you take care of your body, it shows. You feel more energetic, alert, and ready to take on the day. A very necessary part of feeling healthier is to take in more vitamins and minerals. This article should have given you a great place to start when it comes to balancing your diet!

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How the Microbiome Could Be the Key to New Cancer Treatments

Contact Privacy Cookie Policy Terms of Use How the Microbiome Could Be the Key to New Cancer Treatments The effectiveness of drugs that help the immune system fight cancer cells appears to depend on bacteria in the gut The microbes in human guts, including bacteria, archaea, fungi and viruses, play a significant role in how our bodies respond to diseases and treatments. (ChrisChrisW/iStock) smithsonian.com March 7, 2019
Chemical engineer Stephanie Culler was just 13 years old when both her grandmothers died of cancer within six months of each other. Confronting the cruel randomness of the disease is tough for any young teenager, but Culler was further confused by an American Cancer Society poster on her parents’ refrigerator.
“These good food choices may help protect you against certain cancers,” read the poster text accompanying 30 beautifully photographed fruits and vegetables.
But Culler’s grandmothers, one who had lung cancer and the other colon cancer, already ate most of those foods. In fact, her maternal grandmother, an immigrant from Iran, stuck to the traditional Persian cuisine of chopped salads, grilled veggies and pomegranates that would rival any American diet in sheer anti-oxidant glory. Her diet also included gut-friendly fermented foods like homemade yogurt and pickled vegetables. As far as Culler could tell at the time, her grandmothers should have been spared.
The poster on Culler’s family fridge, and the link it suggested between diet and cancer, would eventually lead her to a lab at Johnson & Johnson’s startup division JLABS where she genetically sequences fecal samples. Culler and other oncology researchers hope to answer one of the most pressing questions in current cancer research: Does the quality and diversity of human gut bacteria determine whether people will successfully respond to cancer treatment?
“When we looked at stool from breast and lung cancer patients, we discovered that important bacteria were missing from the microbiome,” Culler says. The absence of certain gut microbes, mostly Firmicutes bacteria , could explain why immune checkpoint inhibitors —drugs that block cancer-friendly proteins and help facilitate the immune system’s response to cancer cells—don’t work on some patients. “We believe that those bacteria are important for the immune system to be able to respond to those drugs,” Culler says.
Along with fellow chemical engineer Steve Van Dien , Culler cofounded Persephone Biome in the summer of 2017 to study the relationship between gut bacteria and cancer. Named for Persephone, the Greek goddess of vegetation who appears in the spring and descends back into the underworld after harvesttime, Culler’s company is gearing up for clinical trials that will test specific gut microbes to see if they improve the function of checkpoint inhibitors in breast and non-small cell lung cancer patients. (A second product will focus on CAR-T cell therapy, which uses patients’ own immune cells that have been genetically engineered to treat their cancer.)
“Our goal is to create therapeutics to convert non-responders into responders,” Culler says, referring to patients who do or do not respond to checkpoint inhibitors. Her company hopes to engineer a mix of selected gut bacteria that can be taken in pill form to heal patients’ microbiomes, which can be damaged by antibiotics and poor diet, as she discussed recently in a talk at TEDx San Diego .
“Even healthy people might be missing these gut microbes, but cancer patients and people with compromised immune systems are more likely to be missing them,” Culler says. “We want to give them back.”
Although at least 70 percent of immune cells are believed to reside in the gut—often called the “second brain”—scientists didn’t become particularly interested in the human microbiome until 2005. A groundbreaking paper published that year suggested that obese mice had different gut bacteria than thin mice. Since then, researchers have explored the idea of swapping out humans’ gut bacteria and have even used fecal microbiota transplants (often called “ poop pills ,” even though they are usually administered as a liquid) to successfully treat people who suffer from inflammatory bowel disease. (However, they’ve yet to develop a weight loss supplement by transferring the bacteria of enviably trim people to the guts of the fat masses.)
Over the last decade, there’s been a flurry of research exploring the microbiome’s role in everything from depression to autism to Parkinson’s disease . Studying the microbiome can help determine which patients are likely to respond to different pain and heart drugs, according to Rob Knight , founding director of the Center for Microbiome Innovation at the University of California San Diego. “We’re extremely interested in the interplay between food, drugs and the gut microbiome,” says Knight, who also cofounded the American Gut Project , a citizen science effort that has collected fecal samples from more than 11,300 participants in 42 countries.
While the connection between gut bacteria and health is becoming clearer, scientists have struggled to successfully manipulate the microbiome as a form of treatment. “We know more than ever about how the microbiome influences chronic disease,” Knight says, “but what we don’t know yet is how to change your microbiome in a particular direction.” (Researchers do agree, however, that probiotics aren’t the godsend some people think they are.)
Last year, three research papers published in Science rocked the cancer field by showing that it might be possible to manipulate the microbiome to affect treatment responses. In a series of “man-meets-mice” interspecies experiments, a French team transplanted human gut bacteria into mice from both successfully treated cancer patients and patients who did not respond to checkpoint inhibitors. Two weeks after the new bacteria had been introduced to the rodents’ guts, the researchers injected cancer cells and checkpoint inhibitors every three days for another two weeks. The drugs worked to reduce tumors in mice that had received human bacteria from successfully treated cancer patients, while the drugs were not effective in the mice that received bacteria from humans who did not respond to treatment.
Teams from the University of Chicago and University of Texas MD Anderson Cancer Center in Houston have conducted similar experiments using gut microbes from metastatic melanoma patients who responded well to checkpoint inhibitors. Those mice improved, too. “We basically put a little tube into the mouse’s esophagus and put in the poop sample. It reconstituted the mouse’s gut so that it now contained microbes from the patient,” says Deepak Gopalakrishnan , a postdoctoral research fellow and lead author of the MD Anderson study.
The next step is clinical trials with humans. The MD Anderson team is studying the possibility of giving patients the missing gut bacteria in the form of spores (which don’t have to be frozen like fecal matter) from donors with favorable microbiomes. Another arm of the trial will test poop pills made from the bacteria of cancer survivors whose tumors disappeared after taking checkpoint inhibitors. And researchers are also tracking patients’ lifestyles, including produce and fiber intake, to connect the dots between cancer drug response rates, gut diversity and diet.
“We know that diet matters, but everyone wants to know what the secret sauce is to change the microbiome to respond better to cancer treatment,” says Jennifer Wargo , a professor of surgery and genomic medicine at the University of Texas who co-authored a review of microbiome science last month. “We simply don’t know that yet.”
Neither does Culler, who still wonders why her grandmothers didn’t respond to the chemotherapy treatments that were available in the mid-1990s. Yet she hopes the same genetic sequencing tools that make it possible to peer into our poop and study bacteria strains will also provide a way to better diagnose tumors and choose the right treatments.
In the meantime, Culler joins a chorus of researchers trying to bring attention to the biggest barrier to their research: lack of stool samples. Scientists need donations from cancer patients, cancer survivors, people with a family history of cancer and everyone else. “I’m always surprised why it’s so difficult to get samples,” Culler says. “People think it’s gross and are embarrassed. But I’m grateful for the cultural acceptance of the poop emoji for destigmatizing it.”
Culler even launched “ Poop for the Cure ,” a research project that offers $50 Visa gift cards for samples. “Hopefully there will be a day when collecting stool will be as routine as collecting blood. Until then, we need everyone to help out.” About Sarah Elizabeth Richards
Sarah Elizabeth Richards is a San Diego-based health and science journalist who writes frequently about biotech. Her work has appeared in The Washington Post, The New York Times, The Wall Street Journal, The Atlantic and Elle Magazine. She is the author of Motherhood, Rescheduled: The New Frontier of Egg Freezing and the Women Who Tried It.

Important Advice About Vitamins And Minerals That You Really Must Learn

It isn’t important whether you are old or young. Men and women, short or tall. Everyone needs certain vitamins and minerals so they can be healthy. If you want to know more, check out the advice below.

When looking for supplements, make sure that you look for those that are in their purest form. For example, Vitamin D3 is the purest form of this supplement and D2 is the synthetic version. This means that the latter may not be as effective and may possibly give you different results than you had hoped for.

If you take children’s vitamins as an adult, you need to take more of them. Children’s supplements contain a lower dose of vitamins, and more than one will typically be needed for an adult. However, be careful that you do not take too many, as that can also be bad.

If you notice that you have been feeling odd after taking particular vitamins and minerals, it would be a good idea for you to leave them alone. Many people believe that vitamins have no side effects, but this is not the truth. Instead of dealing with ill effects, you should look for another way to get what you need.

Glucosamine treats a variety of joint pain issues. This supplement is made from seashells and shark cartilage. Patients have reported glucosamine supplements help relieve knee pain, back pain, glaucoma and the pain associated with osteoarthritis and rheumatoid arthritis; however, there is not sufficient medical evidence to support these claims.

While vegetarian and vegan diets can be very healthy, people often are lacking in certain vitamins and nutrients. Vitamin B12 and iron are two helpful nutrients that often need supplemented by vegetarians. Vegans often need to supplement their calcium and vitamin D intake to ensure they get the proper nutrients.

Cheap food is nutrient poor, so consider what you are eating. For example, eating vegetables out of a can means you’re missing out on fresh, nutrient-rich vegetables instead. Your diet is your key source of vitamins and minerals, and there is no point in taking supplements if you’re eating junk all day long.

Vitamin B3, also known as niacin, is found in B complex supplements, meat, fish, eggs and cereals. This vitamin has been used to treat high cholesterol, dizziness, migraines and other circulation problems, Deficiencies in Vitamin B3 causes aggression, dermatitis, edema, insomnia, mental confusion, diarrhea, weakness, dilated cardiomyopathy and even death.

Everyone needs vitamins and minerals in order to stay healthy. However, many people do not get the right amounts in their food and need to take supplements. Now you know some important information to help you get rid of any vitamin deficiencies.

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With CBD, Cannabis Wellness Market Goes Big

Cannabidiol oil-infused products have opened up a new space for cannabis. Before Melissa McCarthy stepped out on stage last week at the Academy Awards wearing a bunch of stuffed rabbits , she reportedly took a moment to rub her feet with CBD oil to help with the pain associated with the fashionable, but distinctly uncomfortable, ultra-high heels worn by celebrities.
McCarthy isn’t alone in turning to CBD-infused products to treat minor aches and pains. In fact, this year’s Oscars gift bag was full of CBD products. Sales of CBD are predicted to hit $22 billion in three years.
Much of that projected growth is coming from CBD’s newly minted status as a health and wellness product, where it’s treated as a lifestyle oil that relieves pain, fights inflammation and provides consumers with a general sense of well-being, all without the “high” effects that can come with CBD’s sister extract, THC. Until recently, cannabis was looked at as medicinal- or adult-use. With CBD, a third cannabis category — wellness — is emerging.
It’s even catching the eye of retail analysts at Wall Street firms such as Piper Jaffray. Recognizing that stores, such as Sephora, are now dedicating significant shelf space to CBD, one analyst said that she expects to see a lot of growth in the “beauty and the bong” industry.
As the CBD market grows, it will pave the way for THC products (for adult-use). Today, cannabis companies can establish relationships with retailers and build brand awareness with consumers through CBD. They’ll then be ready to add THC to their product lineup when prohibition eventually is lifted.
For now, CBD is being infused into face creams, bath bombs, makeup and dozens of pet products. Proponents say it works on everything from headaches to aching joints, relieves anxiety and skin conditions, and relaxes and rejuvenates all parts of the body . It’s even said to soothe hemorrhoids and stop menstrual cramps . A large part of this expanding category is the edibles market, where CBD is being touted as a superfood as it’s infused into products such as honey, salad dressing, baked goods, snacks and a whole host of beverages .
CBD is going so mainstream that even consumer-goods and media maven Martha Stewart is jumping in. Stewart announced last week that she’s teaming up with Canopy Growth to design and produce new CBD lifestyle products. She’s starting with a line for pets and then plans to introduce products for their human friends.
Cannabis company Tilray also recently signed a $100 million deal with Authentic Brands Group, whose portfolio includes Juicy Couture, Nine West and Jones New York, to develop and distribute cannabis products. Initially that will mean (hemp-derived) CBD items such as foot creams and mints sold in retail stores and malls across the country. Companies like Constellation Brands, makers of Corona beer, and tobacco giant Altria are also getting into the CBD game with billion-dollar investments.
Part of the spike in interest can be attributed to passage of the 2018 Farm Bill , which legalized production of industrial hemp, transforming it into a mainstream agricultural product. It’s certainly led to Tilray’s recent $314 million (U.S. dollars) purchase of Manitoba Harvest, the largest hemp company in the world.
Importantly, the farm bill also explicitly allows hemp-derived CBD products to cross state lines . These changes were followed by removal of hemp-derived CBD oil from the federal government’s Controlled Substances Act , meaning it has been decriminalized across the country at the federal level. That grants CBD privileges at the federal level refused, so far, to THC.
But it’s not entirely smooth sailing. The Food and Drug Administration has yet to issue new rules or guidelines regulating the sale of edible CBD products, leading some jurisdictions — including Maine, Ohio and New York City — to force vendors to pull CBD-infused edibles and beverages from shelves. In December, FDA Commissioner Scott Gottlieb released a statement indicating that CBD products were not legal in edible or supplement form — unless they received FDA approval.
The industry wants CBD listed as “generally recognized as safe,” so it would be classified similarly to vanilla flavoring and caffeine. Joining the industry in this push are at least a dozen lawmakers, who have asked the FDA to reconsider its policy on CBD in food so that it can be manufactured and sold without FDA approval. Gottlieb has shown signs of softening his position. He recently told Congress he would hold the first public hearings on CBD in April, en route to developing formal guidelines.
However the hearings play out, CBD-infused products aren’t going away. Today, nearly 7% of American adults use CBD products. That number is expected to grow to 10% over the next several years, and as CBD continues gaining popularity, it will continue to attract even greater numbers of new consumers into the market.

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FDA Commissioner Scott Gottlieb to resign – Business Insider

Scott Gottlieb, the head of the Food and Drug Administration, is stepping down from his office in about a month, after just under two years in the job. The announcement, made on Tuesday, came as a surprise to many. Gottlieb has been a vocal critic of e-cigarette startups, such as Juul, which he has repeatedly slammed for its popularity among young people. He also presided over the speedy approval of many new drugs and is well-liked in the pharmaceutical community. In his resignation letter, Gottlieb said taking actions against “bad actors that put Americans at risk” was among the FDA’s accomplishments while under his leadership. US Food and Drug Administration (FDA) Commissioner Scott Gottlieb, a well-liked figure who helmed the country’s top food and drug regulator for just less than two years, is resigning.
The surprise announcement was made on Tuesday. Gottlieb, who is reportedly resigning to spend more time with his family, will step down from the office in about a month. The Washington Post first reported the news.
It has been difficult for Gottlieb, who has three young children, to commute back and forth weekly between Washington, DC, and his home in Connecticut, according to The Post.
Gottlieb had been a vocal critic of popular e-cigarette startups, such as Juul, which he has repeatedly slammed for its popularity among teens .
Gottlieb has also won both praise and criticism for the FDA’s speedy approval of many new drugs, including low-cost generic medicines.
In his resignation letter on Tuesday, Gottlieb named taking action against “bad actors that put Americans at risk” among the FDA’s accomplishments while under his leadership.
“We cracked down on bogus stem cell therapies, on sham homeopathy, on unsafe medical device products, on tobacco sales to minors, on unsafe dietary supplements, and on kratom ,” he said in the letter.
In the letter, Gottlieb thanked FDA staffers and expressed gratitude to his family “for their support in enabling me to take on the privilege of serving in this role.”
Read more: A mysterious supplement has a viral following of people who take it for addiction — and researchers say it’s too compelling to ignore
Both President Donald Trump and Alex Azar, the secretary of the Department of Health and Human Services, praised Gottlieb and his work after the announcement.
Azar called him “an exemplary public health leader, aggressive advocate for American patients, and passionate promoter of innovation” on Tuesday.
“Scott’s leadership inspired historic results from the FDA team, which delivered record approvals of both innovative treatments and affordable generic drugs, while advancing important policies to confront opioid addiction, tobacco and youth e-cigarette use, chronic disease, and more,” Azar said in a statement. “The public health of our country is better off for the work Scott and the entire FDA team have done over the last two years.”
Read more: Trump has made his FDA pick — here’s what that could mean for the agency
Gottlieb’s resignation could make some of the FDA’s work on e-cigarettes and tobacco “take a back seat as that was a personal priority for him,” the Raymond James analyst Chris Meekins said.
“Other initiatives Gottlieb has undertaken will continue because his staff is still running the agency, but progress will likely slow,” he said. “The unexpected nature of this should not lead to overreaction. FDA has operated without a permanent commissioner before and can do so again.”
Under Gottlieb’s leadership, the FDA asked a pharmaceutical company to take its opioid medication off the market after the regulator found that its benefits did not outweigh the risks. The regulator has also taken a number of other actions targeting the opioid crisis, including cracking down on online websites selling illegal products.
The FDA did, however, approve a new opioid product despite objections from health advocates , who worried about putting a potent and addictive medication on the market in the midst of the US’s opioid crisis.
Gottlieb, 46, had a long career in the healthcare industry before starting at the FDA. A physician, he also was a venture partner at the venture-capital firm New Enterprise Associates. Gottlieb had also previously served at the FDA as deputy commissioner during George W. Bush’s presidency.
Lydia Ramsey contributed reporting.